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Liquid Phase Peptide Synthesis (LPPS)
UNIBIOCHEM has developed expertise in the solution phase manufacture of small peptides, the ultimate products most often derived from amino acids. The choices of protection group, activating group, order of addition and coupling agent lead to numerous alternate potential peptide synthesis routes. Our experience in the manufacture of the protected amino acids as well as solution phase coupling allows us to quickly target the most cost effective process. UNIBIOCHEM's efficient production of amino acid derivatives provides the critical raw materials for peptide fragments, which we have manufactured by solution phase on a metric ton scale.

Solid Phase Peptide Synthesis (SPPS)

UNIBIOCHEM has equipped with solid phase peptide synthesis instruments such as high-pressure liquid chromatograph and analytical apparatus and so on, enabling us to offer peptide raw materials from gram base to kilogram base.

Peptide Synthesis Characters

Simple to complex

Linear to cyclized

Long sequences peptide up to 140 mer

From small to large scale

Different purity level (desalted, >75%, >85%, >90%, >95%, >98% and even above 99%)

Wide variety of modifications (from biotinylation to phosphorylation, to dye labeling, and much more…)

Peptides - protein bioconjugation

Purification at different scales

Protected Amino Acids
Both solid phase peptide synthesis and solution phase peptide synthesis are demanding a growing array of protected amino acids. These peptide syntheses require amine protection, side·CHAin protection, and often acid activation or protection. The addition order of the protecting groups can have a significant influence on both the cost and quality of a particular derivative. UNIBIOCHEM has extensive experience in kilos-to-tons manufacturing of this wide array of protected amino acids.

Alpha-Amine Protection	Side·CHAin Protection	Carboxyl Protection
Acetyl-	Benzyl-	Benzyl-
Boc-	tert-Butyl-	Cyclohexyl ester-
Cbz-	Trityl-	Ethyl-
Fmoc-	Tosyl-	Methyl-
Trityl-	Nitro-	tert-Butyl-
etc.	etc.	etc.

Unnatural Amino Acids & Derivatives

Unnatural amino acids continue to gain importance in drug development. Reliable, cost-effective commercial supply of these intermediates is crucial for a successful drug launch. UNIBIOCHEM employs the most cost-effective manufacturing processes to provide high-quality unnatural amino acids on an industrial scale.

UNIBIOCHEM have developed expertise in both enzymatic and chemical routes to unnatural amino acids. The acylase route is a well-established, cost-effective process for producing both enantiomers of many unnatural amino acids. Hydantoinase enzymes can be used to provide high yields of high-purity D form amino acids. Other enzymes, including transaminase and nitrilase, are also evaluated in select situations. Non-enzymatic (chemical) processes, including asymmetric hydrogenation, chiral auxiliary and classical resolution methods, are also employed by UNIBIOCHEM.

Chiral Compounds
UNIBIOCHEM takes its unnatural amino acids "downstream" to the manufacture of many complex chiral intermediates. Multiple adjacent chiral centers, required for an increasing number of developmental drugs, can be accessed through amino acid derivative chemistry. The chemistry required for these derivatives, including hydrogenation, grignard and hydride additions, condensations reactions and others, has been practiced on a multi-ton scale at UNIBIOCHEM. Most of this chemistry is carried out under confidentiality protocol.

Chiral Technology

Asymmetric Catalysis

Biotransformation

Chiral Pool Synthesis

Chiral Sulfinamide Template

Enzyme Resolution

Chiral Compounds

Unnatural α-Amino Acids, β-Amino Acids & γ-Amino Acids

Chiral Alcohols, Acids, Amines

CRO & CMO

Chiral synthesis	Boronic acid synthesis	Carbonhydrate synthesis
Alkylation	Azide Reactions	Bromination
Coupling reactions	Cyanation	Diazotization
Grinard reactions	Halogenation reactions	Hydrogenation
Nitration	Ozonolysis	Thiophosgene
- Reaction pressures ranges from 0.1mmHg to 100 bar
- Reaction temperatures ranges from -80°C to +300 °C

Custom Project Management

Sales and marketing staff of UNIBIOCHEM will make initial discussions with customers on potential projects. Such discussions are often under a confidentiality disclosure agreement (CDA). Both parties will exchange information and come an agreement on the range and progress of the project. On this basis, both two sides will make efforts to ensure a successful execution of customer's project.

Our sales and marketing staff are ready to provide information about services and capabilities of UNIBIOCHEM as well as obtain an overview of the customer's requirements. Early in this process, a project manager is assigned to carry out negotiation on technology after gaining support from other relevant departments at UNIBIOCHEM, thus can make a final agreement with the customer.

Once an agreement is in effect, a multi-disciplinary project team is formed under the direction of the project team leader. This project team consists of members with many relevant functions- including sales, R&D, manufacturing, QA/QC, procurement, and any other necessary department that deem to ensure a successful fulfillment of the project's objectives.

The project manager becomes the customer's key liaison at UNIBIOCHEM , which keep the customer well informed of the schedule of the project from the beginning to the end. The main purpose is to ensure the delivery of the project on time and on corresponding budget as well as realizing the quality SPECIFICATIONSs expected by the customer.