Liquid
Phase Peptide Synthesis (LPPS)
UNIBIOCHEM has developed expertise in the solution phase manufacture
of small peptides, the ultimate products most often derived
from amino acids. The choices of protection group, activating
group, order of addition and coupling agent lead to numerous
alternate potential peptide synthesis routes. Our experience
in the manufacture of the protected amino acids as well as solution
phase coupling allows us to quickly target the most cost effective
process. UNIBIOCHEM's efficient production of amino acid derivatives
provides the critical raw materials for peptide fragments, which
we have manufactured by solution phase on a metric ton scale. |
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Solid
Phase Peptide Synthesis (SPPS) |
UNIBIOCHEM
has equipped with solid phase peptide synthesis instruments
such as high-pressure liquid chromatograph and analytical apparatus
and so on, enabling us to offer peptide raw materials from gram
base to kilogram base. |
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Peptide
Synthesis Characters |
Simple to complex |
Linear to cyclized |
Long sequences peptide up to 140 mer |
From small to large scale |
Different purity level (desalted, >75%, >85%, >90%,
>95%, >98% and even above 99%) |
Wide variety of modifications (from biotinylation to phosphorylation,
to dye labeling, and much more…) |
Peptides - protein bioconjugation |
Purification at different scales |
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Protected
Amino Acids
Both solid phase peptide synthesis and solution phase peptide
synthesis are demanding a growing array of protected amino acids.
These peptide syntheses require amine protection, side·CHAin
protection, and often acid activation or protection. The addition
order of the protecting groups can have a significant influence
on both the cost and quality of a particular derivative. UNIBIOCHEM
has extensive experience in kilos-to-tons manufacturing of this
wide array of protected amino acids. |
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Alpha-Amine
Protection
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Side·CHAin
Protection
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Carboxyl
Protection
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Acetyl- |
Benzyl- |
Benzyl-
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Boc- |
tert-Butyl- |
Cyclohexyl
ester-
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Cbz- |
Trityl- |
Ethyl-
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Fmoc- |
Tosyl- |
Methyl-
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Trityl- |
Nitro- |
tert-Butyl-
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etc. |
etc. |
etc.
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Unnatural
Amino Acids & Derivatives |
Unnatural
amino acids continue to gain importance in drug development.
Reliable, cost-effective commercial supply of these intermediates
is crucial for a successful drug launch. UNIBIOCHEM employs
the most cost-effective manufacturing processes to provide
high-quality unnatural amino acids on an industrial scale. |
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UNIBIOCHEM
have developed expertise in both enzymatic and chemical
routes to unnatural amino acids. The acylase route is
a well-established, cost-effective process for producing
both enantiomers of many unnatural amino acids. Hydantoinase
enzymes can be used to provide high yields of high-purity
D form amino acids. Other enzymes, including transaminase
and nitrilase, are also evaluated in select situations.
Non-enzymatic (chemical) processes, including asymmetric
hydrogenation, chiral auxiliary and classical resolution
methods, are also employed by UNIBIOCHEM. |
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Chiral
Compounds
UNIBIOCHEM takes its unnatural
amino acids "downstream" to the manufacture of many
complex chiral intermediates. Multiple adjacent chiral
centers, required for an increasing number of developmental
drugs, can be accessed through amino acid derivative chemistry.
The chemistry required for these derivatives, including hydrogenation,
grignard and hydride additions, condensations reactions and
others, has been practiced on a multi-ton scale at UNIBIOCHEM.
Most of this chemistry is carried out under confidentiality
protocol. |
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Chiral
Technology |
Asymmetric Catalysis |
Biotransformation |
Chiral Pool Synthesis |
Chiral Sulfinamide Template |
Enzyme Resolution |
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Chiral
Compounds |
Unnatural α-Amino Acids, β-Amino Acids & γ-Amino Acids |
Chiral Alcohols, Acids, Amines |
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Chiral
synthesis |
Boronic
acid synthesis |
Carbonhydrate
synthesis |
Alkylation |
Azide
Reactions |
Bromination |
Coupling
reactions |
Cyanation |
Diazotization |
Grinard
reactions |
Halogenation
reactions |
Hydrogenation |
Nitration |
Ozonolysis |
Thiophosgene |
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Reaction pressures ranges from 0.1mmHg to 100 bar |
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Reaction temperatures ranges from -80°C to +300 °C |
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Custom
Project Management |
Sales
and marketing staff of UNIBIOCHEM will make initial discussions with
customers on potential projects. Such discussions are often under
a confidentiality disclosure agreement (CDA). Both parties will exchange
information and come an agreement on the range and progress of the
project. On this basis, both two sides will make efforts to ensure
a successful execution of customer's project. |
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Our
sales and marketing staff are ready to provide information about services
and capabilities of UNIBIOCHEM as well as obtain an overview of the
customer's requirements. Early in this process, a project manager
is assigned to carry out negotiation on technology after gaining support
from other relevant departments at UNIBIOCHEM, thus can make a final
agreement with the customer. |
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Once
an agreement is in effect, a multi-disciplinary project team is formed
under the direction of the project team leader. This project team
consists of members with many relevant functions- including sales,
R&D, manufacturing, QA/QC, procurement, and any other necessary
department that deem to ensure a successful fulfillment of the project's
objectives. |
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The
project manager becomes the customer's key liaison at UNIBIOCHEM ,
which keep the customer well informed of the schedule of the project
from the beginning to the end. The main purpose is to ensure the delivery
of the project on time and on corresponding budget as well as realizing
the quality SPECIFICATIONSs expected by the customer. |
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